Résumé
Tumor cells undergo genetic and epigenetic alterations to sustain rapid proliferation by reprogramming their metabolism. A hallmark of this process is the Warburg effect, characterized by a shift from oxidative phosphorylation to glycolysis, even under normoxic conditions. This adaptation results in enhanced glucose uptake mediated by GLUT transporters, which recognize various carbohydrate substrates. Exploiting this feature has enabled the development of diagnostic and therapeutic tools. In this work, we focus on the design of lanthanide luminescent bioprobes (LLBs) based on glyconjugated europium complexes. The probes are built on a triazacyclononane chelating scaffold functionalized with three polyconjugated aromatic antennas, providing high stability in biological media, biocompatibility, and favorable spectroscopic properties. Additionally, a PEG pendant allows for molecular conjugation. By introducing different carbohydrate moieties into the lanthanide complex, we aim to enhance cellular uptake via GLUT-mediated transport while improving solubility in biological environments. This strategy enables the development of more efficient LLBs for fluorescence and two-photon microscopy, offering promising applications in tumor imaging.