Cell-of-Origin (COO) Classification, BCL2 and MYC Expression Associated Outcome in Younger Patients Treated By RCHOP Front-Line Therapy Versus Intensive Regimen Followed By Autologous Transplant for De Novo Advanced Diffuse Large B Cell Lymphoma (DLBCL) : Results of the French Prospective Multicenter Randomized Trial Goelams-075

Gaëlle Laboure; Marie-Cecile Parrens; Anjarasoa Tsaranazy; Magali Bordier; Steven Le Gouill; Vincent Delwail; Rémy Gressin; Jerome Cornillon; Gandhi Damaj; Charles Yves Foussard; Hervé Maisonneuve; Eric Deconinck; Guillaume Cartron; François Dreyfus; Emmanuel Gyan; Laurent Sutton; Nadine Morineau; Magda Alexis; Anne Banos; Diane Damotte; Anne Moreau; Françoise Kraeber-Bodéré; Delphine Rossille; Thierry Fest; Thierry Lamy; Noel Milpied

Cell-of-Origin (COO) Classification, BCL2 and MYC Expression Associated Outcome in Younger Patients Treated By RCHOP Front-Line Therapy Versus Intensive Regimen Followed By Autologous Transplant for De Novo Advanced Diffuse Large B Cell Lymphoma (DLBCL) : Results of the French Prospective Multicenter Randomized Trial Goelams-075

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Cell-of-Origin (COO) Classification, BCL2 and MYC Expression Associated Outcome in Younger Patients Treated By RCHOP Front-Line Therapy Versus Intensive Regimen Followed By Autologous Transplant for De Novo Advanced Diffuse Large B Cell Lymphoma (DLBCL) : Results of the French Prospective Multicenter Randomized Trial Goelams-075

Gaëlle Laboure, Marie-Cecile Parrens, Anjarasoa Tsaranazy, Magali Bordier, Steven Le Gouill, Vincent Delwail, Rémy Gressin, Jerome Cornillon, Gandhi Damaj, Charles Yves Foussard, …

55th Annual Meeting and Exposition of the American-Society-of-Hematology (La Nouvelle Orléans, United States, 07/12/2013–13/12/2013)

12/2015

Abstract

The prognostic value of COO classification by immunohistochemistry (IHC) for de novo untreated advanced DLBCL remains controversial after Rituximab-based frontline therapy. Other biomarkers such as BCL2 or MYC protein expression have been proposed to predict survival. IHCcharacteristics were investigated in a large multicenter randomized study.

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Title: Cell-of-Origin (COO) Classification, BCL2 and MYC Expression Associated Outcome in Younger Patients Treated By RCHOP Front-Line Therapy Versus Intensive Regimen Followed By Autologous Transplant for De Novo Advanced Diffuse Large B Cell Lymphoma (DLBCL) : Results of the French Prospective Multicenter Randomized Trial Goelams-075
Creators - without role: Gaëlle Laboure - Centre Hospitalier Universitaire de Bordeaux
Marie-Cecile Parrens - Centre Hospitalier Universitaire de Bordeaux
Anjarasoa Tsaranazy - Centre Hospitalier Universitaire de Bordeaux
Magali Bordier - Centre Hospitalier Universitaire de Bordeaux
Steven Le Gouill - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
Vincent Delwail - Service d'Anatomie et de Cytologie Pathologiques [Poitiers]
Rémy Gressin - Institut d'oncologie/développement Albert Bonniot de Grenoble
Jerome Cornillon - Centre Hospitalier Universitaire de Saint-Étienne
Gandhi Damaj - Charmo University
Charles Yves Foussard - Centre Hospitalier Universitaire d'Angers
Hervé Maisonneuve - Service d'hématologie
Eric Deconinck - Service d'Hématologie [CHRU Besançon]
Guillaume Cartron - Laboratory of Pathogens and Host Immunity
François Dreyfus - Service d'hématologie
Emmanuel Gyan - Service d'hématologie
Laurent Sutton - Centre Hospitalier Victor Dupouy
Nadine Morineau - Centre Catherine-de-Sienne [Nantes]
Magda Alexis - Centre hospitalier régional d'Orléans
Anne Banos - Hôpital de Bayonne
Diane Damotte - Centre de Recherche des Cordeliers
Anne Moreau - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
Françoise Kraeber-Bodéré - Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers
Delphine Rossille - Laboratoire d'Hematologie
Thierry Fest - Microenvironnement et cancer
Thierry Lamy - Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Noel Milpied - Service d'Hématologie et Thérapie Cellulaire
Conference: 55th Annual Meeting and Exposition of the American-Society-of-Hematology (La Nouvelle Orléans, United States, 07/12/2013–13/12/2013)
Identifiers: 9934206209311
Academic Unit: Institut de Génétique Moléculaire de Montpellier - IGMM; Laboratory of Pathogens and Host Immunity - LPHI
Language: English
Resource Type: Conference poster
Local Fields: hal-01290432