Abstract
ZACAM is the first French LTSER platform explicitly dedicated to One Health and Full Health approaches, situated within the Camargue Biosphere Reserve, a Mediterranean deltaic region. It investigates health–environment interactions through four main research axes: zoonotic pathogens, antimicrobial resistance, ecotoxicology, and environmental mental health. Embracing interdisciplinarity, long-term monitoring, and data sharing, ZACAM supports participatory knowledge co-production for territorial resilience. Its ZOOCAM project models zoonotic risks through local stakeholder engagement. ZACAM bridges science, policy, and society through integrative health strategies.