Résumé
This chapter provides a conspectus on the state of nuclear architecture today in infectious diseases with a heavy focus on chromosome reorganization. Chromatin is a complex of DNA and proteins, which forms chromosomes within the nucleus of eukaryotic cells. Recent studies in several organisms have investigated the changing chromosome organization during disease progression and have highlighted the importance of chromatin structure for the overall biology of infectious disease agents. Although most of the research of nuclear architecture in eukaryotic pathogens has focused on Plasmodium species, recent research has revealed new insights in nuclear architecture in other infectious disease agents. There is much to be learned about the interactions of pathogens and nuclear architecture, both in the infectious disease agent itself as well as in the host cell. The study of the eukaryotic nuclear organization has at least partially revised our vision of gene regulation. Pathogens such as apicomplexans and trypanosomes can also affect host nuclear architecture in their favor.