Résumé
Radiopharmaceutical therapy (RPT) is a radiotherapeutic modality that is predicated on the specific irradiation of tumours by radiolabelled biomolecules directed against tumour cells or their microenvironment. In contrast to conventional external beam radiotherapy, RPT is characterized by heterogeneous and continuous low dose rate irradiation and can use both high- to low-linear energy transfer depending on the radionuclide chosen. In light of these properties, the radiobiology of RPT must be specifically addressed. Furthermore, given the increasing number of patients treated by RPT, the study of radiobiology should no longer be restricted to preclinical experiments and should be extended to clinical research. The implementation of clinical radiobiology requires the analysis of patient samples and the use of non-invasive imaging approaches to extract tumour features that are indicative of response to RPT.