Regulation of the p53 Tumor‐Suppressor Protein by Ubiquitin and Ubiquitin‐Like Molecules

Dimitris P. Xirodimas

doi:10.1002/9783527620234.ch2

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Chapitre d'ouvrage

Regulation of the p53 Tumor‐Suppressor Protein by Ubiquitin and Ubiquitin‐Like Molecules

Dimitris P. Xirodimas

Protein Degradation: The Ubiquitin‐Proteasome System and Disease, Volume 4, pp.21-45

Wiley‐VCH Verlag GmbH & Co. KGaA

24/10/2007

DOI: https://doi.org/10.1002/9783527620234.ch2

Résumé

p53

protein degradation

protein regulation by ubiquitin

ubiquitin‐like molecules

This chapter contains sections titled: Functional Domains of p53 The Family of Ubiquitin‐like Molecules E3 Ligases for p53 Modification of p53 with Ubiquitin Requirements for Mdm2‐mediated Ubiquitination of p53 Regulation of p53 Ubiquitination E2 Conjugating Enzymes Interacting Proteins By Other Post‐translational Modifications De‐ubiquitination of p53 SUMO‐1/sentrin/smpt3 NEDD8/Rub1 Therapeutic Intervention through the Ubiquitin Pathway Acknowledgments References

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Détails

Titre: Regulation of the p53 Tumor‐Suppressor Protein by Ubiquitin and Ubiquitin‐Like Molecules
Créateurs - sans rôle: Dimitris P. Xirodimas
Contributeurs - sans rôle: R. John Mayer - University of Nottingham, Queens Medical Center, Nottingham NG7 2UH, United Kingdom
Aaron J. Ciechanover - Technion‐Israel Institute, Dept. of Biochemistry, Afron Street, Bat Galim, 31096 Haifa 31096, Israel
Martin Rechsteiner - University of Utah, Dept. of Biochemistry, 50 N. Medical Drive, Salt Lake City, UT 84132, USA
Détails de publication: Protein Degradation: The Ubiquitin‐Proteasome System and Disease, Volume 4, pp.21-45
Éditeur: Wiley‐VCH Verlag GmbH & Co. KGaA; Weinheim, Germany
Nombre de pages: 25
Identifiants: 99149626309311
Unité académique: Centre de Recherche en Biologie Cellulaire de Montpellier - CRBM
Langue: English
Type de ressource: Book chapter