Résumé
This chapter constitutes an overview of nucleophilic addition of organocopper reagents onto carbonyls and imine derivatives. It aims at the description of these copper-mediated transformations through a selection of the most representative examples. The various aspects of regio-, diastereo- and enantiocontrol of these reactions are surveyed. Whenever available, necessary informations to understand these selectivities are discussed. The first part will describe the general trends of reactivity in the presence of stoichiometric amounts of copper salts. The case of aldehydes, ketones, imines, and acylium derivatives are successively described. The second part will be devoted to copper-catalyzed asymmetric transformations and is organized through the hybridization state of the carbon of the C-Cu bond: sp3 (aliphatic, enolate, and allylic derivatives), sp2 (allenic and vinylic nucleophiles) and sp (acetylenic). The case of the pyridinium salts (and related) as well as the acyl chlorides (and related) are evoked in a last miscellaneous part.