Résumé
A 14-mer peptide derived from the HIV Tat protein was shown to translocate efficiently through the plasma membrane [1], Basic amino acid residues in this highly cationic peptide are responsible for its internalization [2]. Non-permeant peptides, antisense oligonucleotides, proteins and even particulate material can be efficiently internalized when chemically conjugated or genetically fused to this Tat peptide. However, the mechanism of this uptake still remains to be elucidated.