Résumé
Zebrafish have a remarkable ability to generate new neurons throughout life and to regenerate those neurons after injury or cell loss. These properties make zebrafish an attractive experimental system to study development and regeneration of dopaminergic neurons during and postembryogenesis. These and other characteristics of the zebrafish also generated a strong interest in this species as a model for neurodegenerative disorders such as Parkinson's disease. The anatomy and development of zebrafish dopaminergic systems are examined here with a particular emphasis on the transcriptional regulators and signaling pathways involved. Various experimental approaches to ablate dopaminergic neurons, either with drugs or through a chemogenetic approach, are presented. Finally, recent efforts to examine dopaminergic neuron regeneration are reviewed.