Résumé
This book, coordinated by Olivier Coux and assisted by Véronique Baldin, Guillaume Bossis, and Denis Tempé, delves into the intricate world of proteolysis, ubiquitin, and ubiquitin-like proteins. It highlights the evolution of proteolysis from a neglected area to a critical function in biological processes, essential for the regulation of protein functions and cellular processes. The book explores the ubiquitin-proteasome system, its role in protein degradation, and its broader implications in cellular regulation, emphasizing its significance recognized by the Nobel Prize in Chemistry in 2004. It also discusses the system's association with diseases like Parkinson's and the potential therapeutic strategies involving ubiquitin conjugation systems.